Opportunity Information: Apply for RFA AT 17 001
The NIH-DoD-VA Pain Management Collaboratory - Pragmatic Clinical Trials Demonstration Projects (UG3/UH3) funding opportunity (RFA AT 17-001) is a cooperative agreement program run by the National Institutes of Health in partnership with the Department of Defense and the Department of Veterans Affairs. Its central aim is to build and prove the ability of military and veteran health care systems to run efficient, cost-effective, large-scale pragmatic clinical trials that test non-pharmacological approaches to pain management, along with strategies that address common co-occurring conditions in service members, veterans, and their families. In practical terms, the opportunity is designed to move evidence-based, real-world pain care research into the places where these patients actually receive care, rather than relying only on tightly controlled, highly selective traditional clinical trial settings.
The awards use a two-phase UG3/UH3 structure that is submitted as a single application but funded in stages. The first stage is a two-year UG3 planning phase that is explicitly milestone-driven, meaning applicants are expected to lay out concrete feasibility and readiness benchmarks and then meet them. This planning period is meant to support the detailed work needed to launch a pragmatic trial inside complex health care delivery organizations, such as refining the protocol for real-world implementation, confirming recruitment and workflow feasibility, aligning with clinical operations, finalizing outcome measures and data collection processes, and resolving regulatory and logistical issues. Only projects that meet the pre-specified scientific milestones and feasibility requirements during UG3 are eligible to transition to the UH3 phase, which supports full implementation of the pragmatic clinical trial Demonstration Project.
A defining feature of this program is the emphasis on pragmatic trials embedded in health care systems serving military and veteran populations. The focus is on interventions that are non-pharmacological (for example, behavioral, rehabilitative, integrative, or systems-based approaches rather than medications) and that can be delivered at scale in real clinical environments. The Collaboratory model also anticipates a broader infrastructure-building payoff: beyond answering individual intervention questions, the initiative is meant to strengthen the long-term capacity of the DoD and VA health care delivery organizations, and their research partners, to conduct ongoing, system-embedded clinical research that is scalable and cost-conscious.
The outcomes of interest are clearly oriented toward patient-centered and operationally meaningful results. Primary outcomes include pain and pain reduction, functional ability in daily life, quality of life, and patterns of medication use, including reduction or discontinuation where appropriate. The FOA also encourages secondary outcomes that capture comorbid conditions or other health issues that commonly co-occur in these populations, recognizing that pain in military and veteran communities often intersects with other physical, psychological, or behavioral health challenges.
Because it is a cooperative agreement, awardees should expect substantial involvement from the funding partners compared to a typical research grant. The announcement notes the expectation that a Coordinating Center will be established to provide national leadership and technical expertise for health care system-focused research, including support that can help UG3/UH3 applicants and projects navigate the complexities of pragmatic trials in large delivery organizations. In effect, applicants are not only proposing a trial, but also joining a larger collaborative framework intended to harmonize methods, accelerate learning, and solve shared implementation barriers across projects.
Eligibility is broad and includes many types of U.S.-based organizations and governments. Eligible applicants span state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities. The FOA also explicitly highlights categories such as Historically Black Colleges and Universities, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Foreign institutions (non-U.S. entities) are not eligible to apply as primary applicants, but non-U.S. components of U.S. organizations may participate, and foreign components as defined under NIH policy are allowed.
Administratively, the opportunity is listed under NIH with a discretionary opportunity category and a cooperative agreement funding instrument type. It is associated with multiple CFDA numbers (93.213, 93.273, 93.279, 93.313, 93.361, 93.853, 93.865). The original closing date provided in the source material is March 3, 2017, and the posting creation date is December 12, 2016. The award ceiling and expected number of awards are not specified in the provided summary data, which typically means applicants would need to consult the full FOA for budget guidance, limits, and program-specific expectations.
Overall, this FOA is best understood as a targeted effort to generate practical, deployable evidence on non-drug pain management strategies in military and veteran health systems, while simultaneously strengthening the national infrastructure and know-how for running pragmatic clinical trials across DoD and VA care settings. It rewards proposals that can demonstrate readiness to work inside real clinical operations, measure outcomes that matter to patients and health systems, and meet rigorous planning milestones before moving into full-scale trial execution.Apply for RFA AT 17 001
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "NIH-DoD-VA Pain Management Collaboratory - Pragmatic Clinical Trials Demonstration Projects (UG3/UH3)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.273, 93.279, 93.313, 93.361, 93.853, 93.865.
- This funding opportunity was created on 2016-12-12.
- Applicants must submit their applications by 2017-03-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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