Opportunity Information: Apply for RFA AG 16 022
Aging Research on Stress and Resilience to Address Health Disparities in the United States (R01) (Funding Opportunity Number RFA-AG-16-022) is a National Institutes of Health grant opportunity designed to push forward interdisciplinary research on why health outcomes in later life differ across priority health disparity populations in the United States. The central idea is that stress exposure, how the body responds to stress, and the ability to resist or recover from stress (stress resilience) can shape aging trajectories in ways that contribute to unequal burdens of disease and disability. The FOA is specifically looking for studies that do more than simply document disparities; it prioritizes research that clarifies mechanisms and pathways that connect stress-related factors to aging-relevant health outcomes.
The opportunity emphasizes linking stress to concrete, high-impact outcomes that matter for older adults and for population health, including mortality, cognitive impairment, multiple chronic conditions, disability, and quality of life. Applicants are encouraged to treat stress broadly and realistically, taking into account the environments people live in, the sociocultural contexts they navigate, the behaviors they adopt or are constrained into, and the biological changes that accumulate over time. In practice, this could mean integrating measures of neighborhood conditions, discrimination, caregiving strain, economic insecurity, or social isolation with behavioral pathways such as sleep, physical activity, diet, substance use, and healthcare engagement, alongside biological indicators such as inflammatory markers, neuroendocrine function, cardiometabolic risk, or other stress-response systems. The FOA is fundamentally about connecting these layers into coherent explanatory models that show how stress and resilience get "under the skin" to influence aging and health disparities.
Because the announcement is framed as an R01, it supports full-scale research projects that can test hypotheses rigorously, often with multi-year study designs, strong analytic plans, and potentially team-based approaches that draw from aging research, epidemiology, psychology, sociology, neuroscience, behavioral science, and related fields. The announcement explicitly aims to stimulate interdisciplinary work, which signals that proposals are expected to bring together expertise and methods capable of handling complex, multilevel pathways rather than single-factor explanations. While the FOA does not prescribe a single study type, its focus on pathways and linkages suggests that well-justified conceptual frameworks, careful measurement strategies, and analytical approaches suited to mediation, moderation, and multilevel influences would be responsive to the goals.
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include state, county, city or township governments, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments that are federally recognized; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other types of organizations as allowed by NIH. The FOA also highlights additional eligible applicant categories that reflect its health-disparities orientation, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions. At the same time, it clearly excludes non-domestic (non-U.S.) entities, non-domestic components of U.S. organizations, and foreign components as defined under the NIH Grants Policy Statement, meaning the funded work must be fully domestic in scope and implementation.
From an administrative standpoint, the opportunity is categorized as discretionary funding, uses the grant funding instrument, and falls under the health funding activity category with CFDA number 93.866. The source information lists an award ceiling of $500,000. The FOA record shows a creation date of September 18, 2015, and an original closing date of January 13, 2016, indicating that this specific announcement was tied to that historical application cycle.
Overall, the FOA is best understood as a call for rigorous, mechanism-focused aging and health-disparities research that treats stress and resilience as central drivers of unequal aging outcomes in the U.S., and that intentionally connects environmental and sociocultural realities to behavioral patterns and biological processes to explain differences in late-life health.Apply for RFA AG 16 022
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Aging Research on Stress and Resilience to Address Health Disparities in the United States (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2015-09-18.
- Applicants must submit their applications by 2016-01-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: Aging Research on Stress and Resilience to Address Health Disparities in the United States (R01) (RFA-AG-16-022)
What is this funding opportunity?
This is a National Institutes of Health (NIH) research grant opportunity titled "Aging Research on Stress and Resilience to Address Health Disparities in the United States (R01)." The Funding Opportunity Number is RFA-AG-16-022.
What is the main purpose of RFA-AG-16-022?
The purpose is to advance interdisciplinary research explaining why health outcomes in later life differ across priority health disparity populations in the United States, with a central focus on stress exposure, biological responses to stress, and stress resilience as drivers of unequal aging trajectories.
What types of research does the FOA prioritize?
The FOA prioritizes studies that go beyond documenting disparities and instead clarify mechanisms and pathways linking stress-related factors and resilience to aging-relevant health outcomes. The emphasis is on explaining how and why disparities emerge, not just showing that they exist.
What outcomes are considered high-impact and relevant to this FOA?
The FOA highlights outcomes that matter for older adults and population health, including mortality, cognitive impairment, multiple chronic conditions, disability, and quality of life.
How does the FOA define or frame "stress" for the purposes of research?
Stress is framed broadly and realistically. The FOA encourages applicants to incorporate the environments people live in, sociocultural contexts, behavioral pathways, and biological changes that accumulate over time, and to connect these levels in coherent models.
What are examples of stress-related exposures or contexts that could be included in a study?
Examples mentioned include neighborhood conditions, discrimination, caregiving strain, economic insecurity, and social isolation.
What behavioral pathways does the FOA suggest could connect stress to aging outcomes?
The FOA cites behavioral pathways such as sleep, physical activity, diet, substance use, and healthcare engagement.
What biological indicators or systems are relevant under this FOA?
The FOA points to biological indicators such as inflammatory markers, neuroendocrine function, cardiometabolic risk, and other stress-response systems.
What does it mean that the FOA is focused on how stress and resilience get "under the skin"?
It means the FOA is seeking research that connects lived experience and sociocultural/environmental conditions to behavioral patterns and measurable biological processes, and then links those to aging and health-disparity outcomes through explanatory pathways.
What grant mechanism is this opportunity using?
This FOA is framed as an R01, which supports full-scale research projects designed to test hypotheses rigorously, often with multi-year study designs and strong analytic plans.
Is this opportunity intended for interdisciplinary research teams?
Yes. The announcement explicitly aims to stimulate interdisciplinary work and signals that proposals are expected to integrate expertise and methods capable of addressing complex, multilevel pathways rather than single-factor explanations.
Does the FOA require a specific study design?
No single study type is prescribed in the information provided. However, the focus on pathways and linkages suggests that proposals should be grounded in well-justified conceptual frameworks, careful measurement strategies, and analytical approaches suited to mediation, moderation, and multilevel influences.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include various local government units (state, county, city/township), special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, Native American tribal governments (federally recognized), tribal organizations (not federally recognized), public and Indian housing authorities, nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories), for-profit organizations other than small businesses, small businesses, and other NIH-allowed organizations.
Are there specific categories of organizations that the FOA highlights as eligible?
Yes. The FOA highlights categories aligned with health-disparities work, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible?
No. The FOA excludes non-domestic (non-U.S.) entities, non-domestic components of U.S. organizations, and foreign components as defined under the NIH Grants Policy Statement. The funded work must be fully domestic in scope and implementation.
What is the funding instrument and funding type?
The opportunity uses the grant funding instrument and is categorized as discretionary funding.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.866.
Is there an award ceiling mentioned?
Yes. The source information lists an award ceiling of $500,000.
When was this FOA created and what were the key dates listed?
The FOA record shows a creation date of September 18, 2015, and an original closing date of January 13, 2016, indicating the announcement was tied to that historical application cycle.
What is the core research theme of this FOA in plain terms?
The core theme is to explain unequal aging outcomes in the U.S. by modeling how stress exposure and resilience shape behavior and biology over time, and how those pathways lead to differences in late-life disease, disability, cognition, mortality, and quality of life.
Is this FOA mainly about measuring disparities or explaining them?
Based on the information provided, it is mainly about explaining disparities by identifying mechanisms and pathways connecting stress and resilience to aging-related health outcomes, rather than simply documenting differences between groups.
What kinds of disciplines does the FOA suggest could be involved?
The FOA references team-based or interdisciplinary approaches drawing from aging research, epidemiology, psychology, sociology, neuroscience, behavioral science, and related fields.
What should a responsive proposal be able to demonstrate conceptually?
A responsive proposal should connect environmental and sociocultural realities to behavioral patterns and biological processes, forming coherent explanatory models that show pathways from stress and resilience to aging-relevant health outcomes and health disparities.
Browse more opportunities from the same category: Health
Next opportunity: Strengthening the Healthcare System of Vietnam through Capacity Building, Policy Development and Quality Improvement of Laboratory and Clinical Services under the President's Emergency Plan for AIDS Relief (PEPFAR)
Previous opportunity: Fort Hunter Liggett Conservation Support
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA AG 16 022
Applicants also applied for:
Applicants who have applied for this opportunity (RFA AG 16 022) also looked into and applied for these:
| Funding Opportunity |
|---|
| HIV Coinfection Surveillance Strategies for Program Planning in the Central America Region under PEPFAR Apply for CDC RFA GH13 134403CONT16 Funding Number: CDC RFA GH13 134403CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Child Neurologist Career Development Program (CNCDP) (K12) Apply for RFA NS 16 003 Funding Number: RFA NS 16 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Technical Assistance to Accelerate the Elimination of Mother to Child Transmission (EMTCT) of HIV and Improve HIV-Free Child Survival in the Republic of Zambia under PEPFAR Apply for CDC RFA GH13 135002CONT16 Funding Number: CDC RFA GH13 135002CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Strengthening the Capacity to Scale-up HIV Prevention, Care and Treatment Programs in South Sudan under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 157202CONT16 Funding Number: CDC RFA GH15 157202CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Strengthening Systems, Capacity, and Data Collection with a focus on Strategic Information (SI) in South Sudan under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH12 125604CONT16 Funding Number: CDC RFA GH12 125604CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Strengthen the Capacity of Republican Narcology Centers on Practical Applications of Medication-Assisted Treatment Programs in the Kazakhstan, Kyrgyzstan and Tajikistan under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 151502CONT16 Funding Number: CDC RFA GH15 151502CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Strengthening the Zambia Ministry of Health’s Capacity to Provide Leadership to the National HIV/AIDS Response through Coordination, Policy Development, Mentorship and Training under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 160002CONT16 Funding Number: CDC RFA GH15 160002CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Strengthening Clinical and Laboratory services at the National Referral level to improve HIV prevention, care and treatment in the Republic of Zambia under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 160302CONT16 Funding Number: CDC RFA GH15 160302CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Information System Development and Systems Integration Support for National HIV and Health Sector Systems in the Republic of Tanzania under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 158602CONT16 Funding Number: CDC RFA GH15 158602CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Building Sustainable Capacity of the Ministry of Home Affairs to Address HIV and TB Prevention, Care and Treatment in Zambian Prisons and Respond to Child Sexual Abuse and Sexual Gender-Based Violence in the Republic of Zambia under the President’s Apply for CDC RFA GH15 160102CONT16 Funding Number: CDC RFA GH15 160102CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Peer-to-Peer Capacity Building in the Public Sector to Support Management, Leadership and Sustainability of HIV Programs in PEPFAR Countries under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 153202CONT16 Funding Number: CDC RFA GH15 153202CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Implementing Evidence Based Prevention Interventions to Prevent New HIV Infections in the United Republic of Tanzania Under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH12 123604CONT16 Funding Number: CDC RFA GH12 123604CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Development of a Laboratory Network and Society to Implement Quality Systems Improvement Programs toward Accreditation and Laboratory Management under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH12 120104CONT16 Funding Number: CDC RFA GH12 120104CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Supporting Laboratory Strengthening in Resource-Limited Countries under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 136603CONT16 Funding Number: CDC RFA GH13 136603CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Technical Assistance Services to Countries Supported by the President's Emergency Plan for AIDS Relief (PEPFAR) and the Global Fund to Fight HIV/AIDS, Tuberculosis and Malaria Apply for CDC RFA GH13 136803CONT16 Funding Number: CDC RFA GH13 136803CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Strengthening Local Capacity to Develop and Implement Open Source Blood Safety and Laboratory Information Systems in Resource-limited Countries Supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 153302CONT16 Funding Number: CDC RFA GH15 153302CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Supporting the Ministry of Public Health to Integrate Comprehensive Prevention of Mother to Child Transmission of HIV Activities into Maternal and Child Health Services in Cameroon by the Directorate of Family Health (DFH) Cameroon under PEPFAR. Apply for CDC RFA GH11 115605CONT16 Funding Number: CDC RFA GH11 115605CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Technical Collaboration with the People’s Republic of China (PRC) on Innovative Approaches to Increase the Effectiveness of the HIV/AIDS Response in China and Globally under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 136403CONT16 Funding Number: CDC RFA GH13 136403CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Improving Health Research and Evaluation Capacity within the Government of Tanzania under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 158902CONT16 Funding Number: CDC RFA GH15 158902CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Accountable and Coordinated HIV/AIDS Services by Regional Health Management Teams in the United Republic of Tanzania under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH11 112605CONT16 Funding Number: CDC RFA GH11 112605CONT16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA AG 16 022", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.