Opportunity Information: Apply for RFA ES 22 007
This National Institutes of Health (NIH) funding opportunity, RFA-ES-22-007, supports R01 research projects aimed at understanding how telomere status and telomere maintenance biology shape vulnerability or resilience to environmental exposures. The scientific focus is on uncovering the molecular mechanisms that connect environmental insults to telomere dynamics and, in turn, to downstream biological pathways that can drive cellular dysfunction and whole-organism health effects. A central premise of the announcement is that damage or disruption at telomeric regions may be an early, sensitive event that accelerates biological aging processes and increases risk for age-related diseases.
Projects responsive to this FOA are expected to go beyond simple associations and push toward mechanistic insight. The announcement emphasizes studying how telomere maintenance systems (and related pathways) modulate downstream responses that may lead to disease, including cancer, cardiovascular disease, and other aging-linked outcomes such as neurodegeneration. In practical terms, this can include examining how exposures influence telomere integrity, length regulation, telomerase activity, telomere binding proteins, DNA damage responses at chromosome ends, and signaling cascades that translate telomere dysfunction into inflammation, senescence, genomic instability, altered cell fate decisions, or tissue-level impairment. The goal is to better map the chain of events from exposure to telomere-related molecular changes to disease-relevant biology, identifying points that explain why some individuals or systems show susceptibility while others show resilience.
The mechanism is an R01 research grant, and the FOA is explicitly labeled "Clinical Trial Not Allowed," meaning applications should not propose clinical trial designs under NIH definitions. The activity category is Environment and Health, and the CFDA listing provided is 93.113. The opportunity is listed as discretionary and uses the standard NIH grant funding instrument. The original closing date included in the source data is February 14, 2023, and the posting (creation) date is October 21, 2022. The provided record does not specify an award ceiling or the expected number of awards.
Eligibility is broad and includes many common NIH-eligible organization types. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education, since those are categorized separately); for-profit organizations other than small businesses; small businesses; and other entities. The FOA also calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Foreign eligibility is nuanced. Non-domestic (non-U.S.) entities and non-domestic foreign institutions are stated as not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are also not eligible to apply. However, the FOA notes that foreign components, as defined in the NIH Grants Policy Statement, are allowed. In practice, that means a U.S.-based applicant organization may include certain foreign components or collaborations when justified and consistent with NIH policy, even though a non-U.S. institution generally cannot serve as the primary applicant.
Overall, the opportunity is designed to energize and advance the telomere-environment field by funding rigorous mechanistic studies that explain how environmental exposures interact with telomere biology to influence aging-related disease pathways. The expected payoff is clearer biological understanding of telomere dynamics as a vulnerable target of environmental stressors, along with insights that could help identify biomarkers, susceptible populations, or mechanistic intervention points relevant to environmentally influenced chronic disease.Apply for RFA ES 22 007
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Utilizing Telomere Status to Reveal Molecular Mechanisms Underlying Susceptibility and Resiliency in Response to Environmental Exposures (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
- This funding opportunity was created on 2022-10-21.
- Applicants must submit their applications by 2023-02-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (RFA ES 22 007) also looked into and applied for these:
| Funding Opportunity |
|---|
| Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional) Apply for RFA ES 22 010 Funding Number: RFA ES 22 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Accelerating Data and Metadata Standards in the Environmental Health Sciences (R24 Clinical Trial Not Allowed) Apply for RFA ES 23 002 Funding Number: RFA ES 23 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Maintaining and Enriching Environmental Epidemiology Cohorts to Support Scientific and Workforce Diversity (U24 Clinical Trial Not Allowed) Apply for RFA ES 23 003 Funding Number: RFA ES 23 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 23 005 Funding Number: RFA ES 23 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Strategies for Responsibly Reporting Back Environmental Health and Non-Genomic Research Results (R01 Clinical Trial Optional) Apply for RFA ES 23 006 Funding Number: RFA ES 23 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| CCRP Initiative: Chemical Threat Agent Exposure Resource and Coordination Core (ExRC) (U2C Clinical Trial Not Allowed) Apply for RFA ES 23 009 Funding Number: RFA ES 23 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $750,000 |
| Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25 Clinical Trial Not Allowed) Apply for RFA ES 23 012 Funding Number: RFA ES 23 012 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $125,000 |
| Hazardous Materials Worker Health and Safety Training (U45 Clinical Trials Not Allowed) Apply for RFA ES 24 001 Funding Number: RFA ES 24 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 24 003 Funding Number: RFA ES 24 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| HAZMAT Training at DOE Nuclear Weapons Complex (UH4 Clinical Trial Not Allowed) Apply for RFA ES 24 002 Funding Number: RFA ES 24 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| CCRP Initiative: Chemical Threat Agent-induced Pulmonary and Ocular Pathophysiological Mechanisms (R01 Clinical Trial Not Allowed) Apply for RFA ES 24 005 Funding Number: RFA ES 24 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional) Apply for RFA ES 24 004 Funding Number: RFA ES 24 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Epitranscriptomics Crosstalks and Toxicants (EPCOT) (R01 Clinical Trials Not Allowed) Apply for RFA ES 25 001 Funding Number: RFA ES 25 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $500,000 |
| Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional) Apply for RFA ES 25 002 Funding Number: RFA ES 25 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| NIH Blueprint for Neuroscience: Coordination Center for Interoception Research (BPCCIR) (U24, Clinical Trial Not Allowed) Apply for RFA AT 25 004 Funding Number: RFA AT 25 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
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