Opportunity Information: Apply for RFA ES 15 019

The Superfund Hazardous Substance Research and Training Program (P42), run by the National Institute of Environmental Health Sciences (NIEHS) under the National Institutes of Health, funds multi-project Superfund Research Program (SRP) Centers that focus on real-world hazardous substance problems and practical solutions. The intent is to support center-level efforts that bring together biomedical research with environmental science and engineering, so that questions about exposure, health effects, and cleanup are tackled in an integrated way rather than through isolated studies. A defining feature of this opportunity is that applicants are expected to build a coordinated Center made up of multiple connected research projects plus shared “core” functions that keep the program cohesive and outward-facing.

These SRP Centers are designed to be problem-based and solution-oriented, meaning the research is expected to connect clearly to hazardous substances and contaminated environments and to produce outputs that can inform public health decisions, risk management, and remediation. In addition to scientific projects, Centers include cores that cover essential infrastructure and impact activities: administrative coordination, community engagement, research translation (moving findings toward practical use by stakeholders such as regulators, communities, and practitioners), training, and other research support functions. The overall model emphasizes cross-disciplinary collaboration and intentional pathways for communicating results beyond academia.

The program scope is explicitly grounded in the Superfund Amendments and Reauthorization Act of 1986 and centers on four major areas. First, it supports advanced techniques to detect, assess, and evaluate how hazardous substances affect human health, including improved ways to measure exposures and biological responses. Second, it supports methods to assess risks to human health posed by hazardous substances, which can include toxicology, epidemiology, exposure science, and risk modeling approaches. Third, it supports methods and technologies to detect hazardous substances in the environment, such as monitoring tools, analytical chemistry methods, and field-deployable sensing approaches. Fourth, it supports fundamental biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances, aligning with remediation science and engineering and strategies to mitigate harm.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (when not institutions of higher education); for-profit organizations other than small businesses; and small businesses. The opportunity also highlights additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.

Foreign institutions are not eligible to apply as primary applicants, and non-U.S. components of U.S. organizations are not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, which generally means a U.S. applicant organization can include certain well-justified international elements in the work when permitted under NIH policy, even though the award itself is made to an eligible U.S. entity.

From the posted opportunity details, this was a discretionary grant funding opportunity (Funding Opportunity Number RFA ES 15 019) in the education, environment, and health space, associated with CFDA 93.143. The listed award ceiling was $1,750,000, with an anticipated 10 awards, and the original closing date was April 11, 2016. Overall, the grant is structured to build sustained, interdisciplinary Center programs that not only generate high-quality research on hazardous substances but also train the next generation of researchers and translate findings into information and tools that communities, decision-makers, and technical professionals can use.

  • The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Superfund Hazardous Substance Research and Training Program (P42)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.143.
  • This funding opportunity was created on 2015-09-17.
  • Applicants must submit their applications by 2016-04-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,750,000.00 in funding.
  • The number of recipients for this funding is limited to 10 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for RFA ES 15 019

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Frequently Asked Questions (FAQ)

What is the Superfund Hazardous Substance Research and Training Program (P42)?

The Superfund Hazardous Substance Research and Training Program (P42) is a funding program run by the National Institute of Environmental Health Sciences (NIEHS) under the National Institutes of Health (NIH). It funds multi-project Superfund Research Program (SRP) Centers that focus on real-world hazardous substance problems and practical solutions.

What is the main purpose of this funding opportunity?

The purpose is to support Center-level, interdisciplinary efforts that integrate biomedical research with environmental science and engineering. The goal is to address exposure, health effects, and cleanup in a coordinated way, rather than through isolated studies, and to produce results that can inform public health decisions, risk management, and remediation.

What makes this opportunity different from a typical single-project research grant?

A defining feature is that applicants are expected to build a coordinated Center made up of multiple connected research projects plus shared "core" functions. These cores provide infrastructure, coordination, and outward-facing activities that keep the overall program cohesive and impactful.

What kind of award does this opportunity support?

This opportunity supports multi-project Superfund Research Program (SRP) Centers (also described as center-level programs). These Centers are designed to be problem-based and solution-oriented, with multiple projects and shared core components.

What does "problem-based and solution-oriented" mean in this program?

It means the research is expected to connect clearly to hazardous substances and contaminated environments and to produce outputs that can inform public health decisions, risk management, and remediation. The program emphasizes practical solutions and real-world relevance.

What types of research topics are within the program scope?

The program scope is grounded in the Superfund Amendments and Reauthorization Act of 1986 and centers on four major areas: (1) advanced techniques to detect, assess, and evaluate how hazardous substances affect human health, including improved ways to measure exposures and biological responses; (2) methods to assess risks to human health posed by hazardous substances, including toxicology, epidemiology, exposure science, and risk modeling; (3) methods and technologies to detect hazardous substances in the environment, such as monitoring tools, analytical chemistry methods, and field-deployable sensing; and (4) fundamental biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances, aligning with remediation science and engineering and harm mitigation strategies.

Does the program focus only on health research, or also on environmental detection and cleanup?

It covers both. The model is intentionally integrated, bringing together biomedical research (exposure and health effects) with environmental science and engineering (environmental detection, monitoring, and remediation approaches).

What are "cores" in an SRP Center, and why are they required?

Cores are shared functions that provide essential infrastructure and impact activities across the Center. They are used to keep the program coordinated, cohesive, and outward-facing. The opportunity describes core areas such as administrative coordination, community engagement, research translation, training, and other research support functions.

What types of core functions are included in these Centers?

The opportunity describes cores that cover: administrative coordination, community engagement, research translation (moving findings toward practical use by stakeholders such as regulators, communities, and practitioners), training, and other research support functions.

What is meant by "research translation" in this opportunity?

Research translation refers to moving scientific findings toward practical use by stakeholders such as regulators, communities, and practitioners. The program emphasizes intentional pathways for communicating results beyond academia.

Is training part of the expected Center activities?

Yes. The opportunity notes that Centers are expected not only to generate high-quality hazardous substance research but also to train the next generation of researchers.

Who is the sponsoring agency for this opportunity?

The opportunity is run by the National Institute of Environmental Health Sciences (NIEHS) under the National Institutes of Health (NIH).

What is the Funding Opportunity Number (FON) for this grant?

The Funding Opportunity Number listed is RFA ES 15 019.

What is the CFDA number associated with this opportunity?

The opportunity is associated with CFDA 93.143.

What type of funding opportunity is this?

It is described as a discretionary grant funding opportunity in the education, environment, and health space.

What was the maximum award amount (award ceiling) listed?

The listed award ceiling was $1,750,000.

How many awards were anticipated?

The opportunity anticipated 10 awards.

What was the closing date for this opportunity?

The original closing date was April 11, 2016.

What organizations are eligible to apply?

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include: state, county, and city/township governments; special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (when not institutions of higher education); for-profit organizations other than small businesses; and small businesses.

Are minority-serving institutions specifically mentioned as eligible?

Yes. The opportunity highlights additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).

Are faith-based and community-based organizations eligible?

Yes. The opportunity explicitly highlights faith-based or community-based organizations among additional eligible categories.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are listed among additional eligible categories.

Can for-profit companies apply?

Yes. For-profit organizations other than small businesses are listed as eligible applicants, and small businesses are also listed as eligible.

Can foreign institutions apply as the primary applicant?

No. Foreign institutions are not eligible to apply as primary applicants.

Can a non-U.S. component of a U.S. organization apply?

No. Non-U.S. components of U.S. organizations are not eligible to apply.

Are foreign components allowed in the work at all?

Yes, foreign components are allowed as defined by the NIH Grants Policy Statement. In general, this means a U.S. applicant organization may include certain well-justified international elements in the work when permitted under NIH policy, even though the award itself is made to an eligible U.S. entity.

What kinds of real-world impacts does the program emphasize?

The program emphasizes outputs that can inform public health decisions, risk management, and remediation. It also emphasizes communication and translation of results beyond academia to stakeholders such as regulators, communities, and practitioners.

What legal or policy foundation is referenced for the program scope?

The program scope is explicitly grounded in the Superfund Amendments and Reauthorization Act of 1986.

Does the program require collaboration across disciplines?

Yes. The opportunity emphasizes cross-disciplinary collaboration and the integration of biomedical research with environmental science and engineering within a coordinated Center framework.

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