Opportunity Information: Apply for RFA OD 23 015

This NIH funding opportunity (RFA-OD-23-015) is a targeted Request for Applications for revision applications to currently active NIH R01 awards. It sits within the ADVANCE (Advancing Prevention Research for Health Equity) program and is led by the NIH Office of Disease Prevention (ODP) under the Office of the Director, Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI). The main purpose is to add new, time-sensitive work onto an existing R01 by supporting additional studies that develop and evaluate interventions aimed specifically at preventing menthol cigarette use and helping people stop using menthol cigarettes, with a clear emphasis on populations that experience health disparities. Clinical trials are allowed but not required, meaning applicants can propose either clinical-trial or non-clinical-trial research as long as it fits the intervention development and/or evaluation focus.

A key feature of this opportunity is that it is not for brand-new standalone R01 projects; it is for revisions (formerly referred to as competitive revisions) to active R01 grants. In practice, that means the applicant needs to already hold an NIH-funded R01 that is currently active, and the proposed menthol-focused aims should logically extend, enhance, or accelerate the parent award rather than replace it. The revision mechanism is intended to enable research teams to build onto existing infrastructure, cohorts, partnerships, data systems, or intervention platforms to answer important questions about menthol smoking prevention and cessation in a faster and more efficient way than starting from scratch.

The public health target is menthol cigarettes, which have been widely associated with increased initiation and greater difficulty quitting for many smokers, and have been disproportionately marketed and used in several communities experiencing inequities. Consistent with the ADVANCE health equity framing, the solicitation centers on interventions for populations that experience health disparities, which can include communities defined by race and ethnicity, socioeconomic position, geography, disability status, sexual and gender minority status, or other factors linked to unequal health burdens. The research supported is intended to be intervention-focused (developing, adapting, testing, or evaluating prevention and cessation approaches), rather than purely descriptive surveillance work.

Eligibility is broad across many U.S.-based organization types that commonly apply for NIH grants. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations that are not federally recognized; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other organizations. The announcement also explicitly highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, it draws clear boundaries around foreign involvement: non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed under this RFA.

From an administrative standpoint, the opportunity is categorized as a discretionary grant under the health and education activity space and is associated with multiple CFDA numbers (93.121, 93.233, 93.279, 93.307, 93.313, 93.393, 93.837, 93.838, 93.839, 93.840), reflecting the NIH’s multi-institute structure and the way prevention and tobacco-related research can span several NIH program areas. The posted award ceiling is $200,000 (generally interpreted as the maximum additional amount that can be requested for the revision, subject to NIH budget rules and the parent award context). The original closing date listed for the RFA was June 19, 2023, and the opportunity was created on March 30, 2023. No expected number of awards is specified in the provided data, which typically means the final number depends on application volume, quality, and available funds.

Overall, the RFA is designed to quickly expand the evidence base for menthol cigarette prevention and cessation strategies by leveraging ongoing R01 projects and directing added resources toward intervention research that can reduce tobacco-related inequities. Applicants are expected to propose well-justified additional aims that fit the parent R01, focus on populations experiencing health disparities, and generate practical, testable knowledge about what helps prevent menthol cigarette use and what improves quitting outcomes in real-world settings.

  • The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Request for Applications (RFA): Revision Applications to Support Research on Prevention and Cessation of Menthol Cigarette Use in Populations that Experience Health Disparities (R01, Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.233, 93.279, 93.307, 93.313, 93.393, 93.837, 93.838, 93.839, 93.840.
  • This funding opportunity was created on 2023-03-30.
  • Applicants must submit their applications by 2023-06-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for RFA OD 23 015

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