Opportunity Information: Apply for PAR 18 360

The NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 - Clinical Trial Required), PAR-18-360, is an NIH discretionary grant opportunity run by the National Institute of Dental and Craniofacial Research (NIDCR). It is built to help highly qualified dentist scientists who are currently in NIH Intramural postdoctoral fellowship positions move from mentored training to true research independence. The program is structured around a transition: applicants first continue to build their research skills and publication record within the NIH Intramural Research Program under mentorship, and then, once they secure a position at an eligible extramural institution, they receive independent support to launch and sustain their own research program as a new investigator outside NIH.

A defining feature of this particular FOA is that it is specifically for candidates who will lead an independent clinical trial as part of their research and career development plan. That can mean running a full independent clinical trial, conducting a clinical trial feasibility study, or leading a standalone ancillary study that is tied to an existing clinical trial, but where the applicant has independent responsibility for the ancillary study. In other words, the expectation is not simply that the applicant will participate in a trial run by someone else, but that they will be the lead investigator for a trial or trial-related study that is central to their path toward independence. If an applicant is not planning to lead an independent clinical trial, or if their intended experience is mainly to gain training by working on a clinical trial led by another investigator, NIDCR directs them instead to apply under the companion announcement (PAR-16-140), which covers the non-independent-clinical-trial path.

Eligibility is broad at the institutional level, which reflects how NIH career transition awards are meant to follow the scientist as they move into an independent job. Eligible applicant organizations include many types of U.S.-based entities such as state, county, city, township, and special district governments; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled universities; private institutions of higher education; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations other than small businesses; and small businesses. The FOA also highlights categories of institutions that may apply, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.

At the same time, there are important limits related to foreign involvement. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply as applicant organizations for this K22. However, foreign components, as NIH defines them in the NIH Grants Policy Statement, are allowed, meaning some elements of the work can involve foreign collaborators or activities if they meet NIH policy requirements and are justified within the application.

From a classification standpoint, this is a grant mechanism in the health area (CFDA 93.121). The listing information provided shows the original closing date as January 7, 2022, and the FOA record indicates it was created on November 15, 2017. The award ceiling and expected number of awards are not specified in the provided source data, which typically means applicants need to consult the full FOA text and NIH policy references for the most current budget structure and any institute-specific limits. Overall, the program is best understood as a career-building bridge for dentist scientists in the NIH intramural environment who are ready to step into independence and who have a clinical trial leadership plan that will serve as a major pillar of their emerging extramural research career.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22-Clinical Trial Required)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
  • This funding opportunity was created on 2017-11-15.
  • Applicants must submit their applications by 2022-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 - Clinical Trial Required) (PAR-18-360)

What is this funding opportunity?

This opportunity is the NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 - Clinical Trial Required), FOA number PAR-18-360. It is an NIH discretionary grant program run by the National Institute of Dental and Craniofacial Research (NIDCR) designed to help dentist scientists move from mentored intramural training to independent extramural research careers.

Who is the sponsoring agency and institute?

The program is administered by the National Institutes of Health (NIH) through the National Institute of Dental and Craniofacial Research (NIDCR).

What is the purpose of the K22 in this announcement?

The purpose is to support highly qualified dentist scientists currently in NIH Intramural postdoctoral fellowship positions as they transition from mentored research training to research independence outside NIH, including the launch and sustainment of an independent research program as a new investigator at an eligible extramural institution.

How is the award structured (what does "career transition" mean here)?

The program is structured as a transition. First, the candidate continues skill-building and strengthens their publication record within the NIH Intramural Research Program under mentorship. Then, after the candidate secures a position at an eligible extramural institution, the award provides independent support to help launch and sustain the candidate's research program outside NIH.

What is the defining feature of this specific FOA?

A defining feature is that the candidate is expected to lead an independent clinical trial as part of their research and career development plan. The focus is on clinical trial leadership as a central element of the transition to independence.

Does this FOA require the applicant to lead a clinical trial?

Yes. This K22 (Clinical Trial Required) is specifically for candidates who will lead an independent clinical trial or a qualifying clinical trial-related study where the candidate has independent responsibility.

What kinds of clinical trial activities can satisfy the "clinical trial required" expectation?

The FOA description indicates the requirement can be met by leading: (1) a full independent clinical trial, (2) a clinical trial feasibility study, or (3) a standalone ancillary study that is tied to an existing clinical trial, provided the applicant has independent responsibility for the ancillary study.

Is it enough to participate in a clinical trial led by someone else?

No. The expectation described is not simply participation in a clinical trial run by another investigator. The candidate should be the lead investigator for a trial or trial-related study that is central to their path toward independence.

What if the applicant is not planning to lead an independent clinical trial?

If an applicant is not planning to lead an independent clinical trial, or if their goal is mainly to gain training by working on a clinical trial led by another investigator, NIDCR directs applicants to the companion announcement PAR-16-140 (the non-independent-clinical-trial path).

Who is this award intended for (career stage and setting)?

This award is intended for highly qualified dentist scientists who are currently in NIH Intramural postdoctoral fellowship positions and who are ready to move from mentored training toward independent extramural research.

Where does the mentored phase take place?

Based on the description provided, the mentored training portion occurs within the NIH Intramural Research Program under mentorship.

When does independent (extramural) support begin?

Independent support begins once the candidate secures a position at an eligible extramural institution, at which point the award supports the launch and sustainment of the candidate's independent research program outside NIH.

What types of organizations are eligible to apply as the applicant organization?

Eligible applicant organizations include many U.S.-based entities such as state, county, city, township, and special district governments; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled universities; private institutions of higher education; nonprofits (501(c)(3) and non-501(c)(3)); for-profit organizations other than small businesses; and small businesses.

Are specific institution categories highlighted as eligible?

Yes. The FOA highlights categories that may apply, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.

Can a non-U.S. (foreign) organization apply as the applicant?

No. Non-domestic (non-U.S.) entities are not eligible to apply as applicant organizations for this K22.

Can a non-U.S. component of a U.S. organization apply?

No. Non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply as applicant organizations for this K22.

Are foreign components allowed at all?

Yes. The description states that foreign components are allowed as NIH defines them in the NIH Grants Policy Statement, meaning some elements of the work can involve foreign collaborators or activities if they meet NIH policy requirements and are justified in the application.

What is the CFDA/assistance listing number and general area?

The opportunity is described as a health-area grant mechanism with CFDA 93.121.

What is the FOA number for this opportunity?

The FOA number is PAR-18-360.

When was this FOA record created and what closing date is shown in the provided data?

The record indicates it was created on November 15, 2017. The listing information provided shows an original closing date of January 7, 2022.

Are the award ceiling and number of expected awards specified in the provided information?

No. The award ceiling and expected number of awards are not specified in the provided source data. The description notes that applicants typically need to consult the full FOA text and NIH policy references for the most current budget structure and any institute-specific limits.

What is the key takeaway about what this program supports?

This program is best understood as a career-building bridge for dentist scientists in the NIH intramural environment who are ready to step into independence and who have a clinical trial leadership plan that will serve as a major pillar of their emerging extramural research career.

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