Opportunity Information: Apply for PA 23 317
This NIH funding opportunity (PA-23-317) supports "competing revision" applications to existing NIH single-project awards, including research grants and cooperative agreements, with clinical trials allowed but not required. The basic idea is that NIH is not asking for entirely new, standalone projects here; instead, it is offering a way for current NIH awardees to request additional support to expand the scope, scale, or capabilities of an already-funded project or program, as long as the requested expansion fits within the scientific mission and priorities of the specific NIH Institute or Center (IC) that issued the original award.
A key restriction is that applicants can only use this announcement if they are responding to a competitive revision Notice of Special Interest (NOSI) published by an NIH Institute or Center. In practice, that means the opportunity is essentially a framework for competitive revisions, while the specific topics and priorities are laid out in individual NOSIs. If there is no relevant NOSI from the awarding IC, then an application cannot be submitted under this NOFO. Because of that structure, prospective applicants typically start by identifying an active NIH award they already hold, then checking whether the awarding IC has released a NOSI calling for competitive revisions in an area that matches the proposed expansion.
Applications are peer reviewed for scientific and technical merit by appropriate NIH Scientific Review Groups, following standard NIH peer review policies and procedures and using the stated review criteria. In other words, these revisions compete for funds and are evaluated rigorously, rather than being handled as a purely administrative supplement. The revision request must make a clear case for why the added activities are important, feasible, and well integrated with the existing funded project, and why the expansion is needed now.
Eligibility is broad in the sense that NIH supports many organization types, but the practical eligibility hinge is being an NIH award recipient seeking a revision to an active project and responding to an IC-issued NOSI. The listing of eligible applicants includes many common categories such as state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized governments); public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The opportunity also explicitly notes additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), certain tribal governments other than federally recognized, regional organizations, non-U.S. (foreign) organizations, and U.S. territories or possessions. The presence of these categories signals that NIH intends the mechanism to be accessible across a wide range of institutional settings, provided the applicant meets the core requirement of holding the underlying NIH award and aligning with a relevant NOSI.
From an administrative standpoint, the announcement is categorized as a discretionary grant funding opportunity, and it spans multiple NIH program areas as reflected by the CFDA numbers listed (93.172, 93.213, 93.242, 93.273, 93.279, 93.307, 93.310, 93.350, 93.394, 93.865). The posted close date is 2026-11-24. The synopsis does not specify an award ceiling or expected number of awards, which generally means the budget and volume will depend on the particular NOSI, the awarding IC, the scope of the requested expansion, and funds available.
In practical terms, the opportunity is best viewed as a pathway for current NIH-funded investigators and organizations to competitively add new aims, broaden study populations, extend methods, build new partnerships, add new sites or capabilities, or otherwise scale up impact in a way that is justified by the original project and responsive to an IC’s targeted interest area. The deciding factor is always whether the proposed revision meaningfully strengthens and extends the parent award while staying consistent with NIH policies, the parent project’s overall direction, and the specific requirements of the NOSI that authorizes submissions under this announcement.Apply for PA 23 317
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172, 93.213, 93.242, 93.273, 93.279, 93.307, 93.310, 93.350, 93.394, 93.865.
- This funding opportunity was created on 2023-11-24.
- Applicants must submit their applications by 2026-11-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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